What adverse effects are associated with cyclosporine?
Common side effects of cyclosporine include:
- High blood pressure.
- Increased hair growth. …
- Swollen or inflamed gums. …
- Numbness or tingling of the hands or feet. …
- Other common side effects are tremors, restlessness, stomach upset, nausea, cramps, diarrhea, headache, and changes in blood sugar.
Which types of adverse reactions has been demonstrated for cyclosporine in the kidney?
The principal adverse reactions of Sandimmune (cyclosporine) therapy are renal dysfunction, tremor, hirsutism, hypertension, and gum hyperplasia.
What does a cyclosporine do?
Cyclosporine is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). It belongs to a group of medicines known as immunosuppressive agents.
What happens if you take too much cyclosporine?
High dosages of cyclosporine can cause liver and kidney toxicity. It can also increase people’s risk of certain types of cancer, especially lymphoma and skin cancer.
What is CNI nephrotoxicity?
CNI nephrotoxicity is manifested either as acute kidney injury (AKI), which is largely reversible after reducing the dose, or as chronic progressive renal disease, which is usually irreversible [2-5].
Does cyclosporine cause hyperkalemia?
Cyclosporine A (CyA) is known to cause hyperkalemia by impairing renal potassium excretion.
Why does cyclosporine cause hypertension?
The exact mechanism of cyclosporine-induced hypertension is uncertain, but several hypotheses have been proposed, including increased prostaglandin synthesis and decreased water, sodium, and potassium excretion.[46,47] Up to 50% of renal transplant patients receiving cyclosporine treatment have reported elevated blood …
Is cyclosporine used for allergy?
Conclusions: Topical cyclosporin A is an effective treatment in the management of severe allergic conjunctivitis with a benefit as a steroid-sparing agent.
Is cyclosporine contraindicated in pregnancy?
-Due to potential effects in the nursing infant, such as immunosuppression, neutropenia, growth retardation, and possible carcinogenesis, this drug is considered contraindicated for use in nursing mothers by the American Academy of Pediatrics.
How does cyclosporine affect blood pressure?
The results demonstrate a highly statistically significant increase in blood pressure associated with cyclosporine. There appears to be a dose-related effect with lower doses (1-4 mg/kg/d) increasing mean BP by an average of 5 mmHg and higher doses (>10 mg/kg/d) increasing mean BP by 11 mmHg on average.
How is cyclosporine nephrotoxic?
Because cyclosporine use is associated with apoptotic mechanisms (see above), defective P-glycoprotein activity or decreased expression could increase the direct nephrotoxic effects of cyclosporine, which would explain the association of ABCB1 genotype or expression with CNI nephrotoxicity in previous human studies.
How does tacrolimus cause hypertension?
Hypertension mediated by tacrolimus is largely caused by activation of the renal sodium chloride cotransporter (NCC), say researchers. In wild-type mice, tacrolimus caused salt-sensitive hypertension and increased levels of phosphorylated NCC, whereas in NCC-knockout mice, it did not affect blood pressure.
Is cyclosporine A Dmard?
The most commonly used DMARD is methotrexate (Trexall®, Rheumatrex®, Otrexup®, Resuvo®). Other DMARDs include sulfasalazine (Azulfidine®), leflunomide (Arava®), hydroxychloroquine (Plaquenil®), Cyclosporine (Neoral®, Sandimmune®), Azathioprine (Imuran®), and Apremilast (Otezla®).
Is cyclosporine an immunosuppressant?
Cyclosporine and cyclosporine (modified) are in a class of medications called immunosuppressants. They work by decreasing the activity of the immune system.
Can you take paracetamol with cyclosporine?
No interactions were found between cyclosporine and Paracetamol.
Does cyclosporine interact with cetirizine?
No interactions were found between cyclosporine and Zyrtec.
Can cyclosporine cause thrombocytopenia?
Other side effects of cyclosporine include: Low white blood cell count (leukopenia) Low platelet count (thrombocytopenia) Severe allergic reaction (anaphylaxis)
Is cyclosporine A biologic?
Cyclosporine and methotrexate are two non-biological systemic treatments for psoriasis (see also the overview on systemic treatments). Both medicines work in different ways by slowing down the skin cell production and reducing inflammation. They are usually taken as tablets, but can also be given as injections.